abstract：:In this paper, we have assessed the role of changing physicochemical parameters and substrate types on the production of α-amylase enzyme from Penicillium chrysogenum, with a view to determining the optimal conditions required for its maximum production. The findings of this research revealed that, at pH 6 using linse...

journal_title：Microbial pathogenesis

authors： Dar GH,Kamili AN,Nazir R,Bandh SA,Jan TR,Chishti MZ

更新日期：2015-11-01 00:00:00

abstract：:We have recently shown that a mouse lung infection model resulting in acute pneumonia could be used for evaluating the protective immunity induced by mucosal vaccines against Vibrio cholerae. In order to gain insight and better understanding of the pathogenicity of V. cholerae infection, we identified and compared pro...

journal_title：Microbial pathogenesis

authors： Kang SS,Baik JE,Yang JS,Cho K,Yun CH,Han SH

更新日期：2015-09-01 00:00:00

abstract：:The oral cavity is regarded as a relevant site for Staphylococcus aureus colonization. However, characterization of virulence mechanisms of oral S. aureus remains to be uncovered. In this study, twenty one S. aureus strains isolated from the oral cavity of Tunisian patients were screened for adherence, invasion and cy...

journal_title：Microbial pathogenesis

authors： Merghni A,Ben Nejma M,Helali I,Hentati H,Bongiovanni A,Lafont F,Aouni M,Mastouri M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:It is generally considered that HLA-Ⅱ genes contribute to the Helicobacter pylori (Hp) infection and disease development process. AIMS:To perform a meta-analysis to explore the relationship between HLA-Ⅱgene polymorphism and host susceptibility to Hp infection. METHODS:Relevant cohort studies, case-control...

journal_title：Microbial pathogenesis

authors： Wang J,Zhang Q,Liu Y,Han J,Ma X,Luo Y,Liang Y,Zhang L,Hu Y

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Since the high morbidity and mortality of candidemia among cancer patients, the epidemiology has been underlined. In recent years, Candida species genotyping has been established, which could provide detail characteristics of epidemiology and has been underscored for candidemia preventing strategies. METHOD...

journal_title：Microbial pathogenesis

authors： Li D,Li X,Xia R,Zhang W,Zheng S,Zhang Q,Bai C,Zhang P

更新日期：2015-04-01 00:00:00

abstract：:Acinetobacter nosocomialis is an important nosocomial pathogen that causes a variety of opportunistic infections; however, pathogenesis of this microorganism has not yet been characterized. The aim of this study was to investigate the secretion of outer membrane vesicles (OMVs) from A. nosocomialis and to determine th...

journal_title：Microbial pathogenesis

authors： Nho JS,Jun SH,Oh MH,Park TI,Choi CW,Kim SI,Choi CH,Lee JC

更新日期：2015-04-01 00:00:00

abstract：UNLABELLED:The outcome of Helicobacter pylori infection has been related to specific virulence-associated bacterial genotypes. The vacuolating cytotoxin (vacA), cagA gene, oipA and babA2 gene are important virulence factor involving gastric diseases. The objective of this study was to assess the relationship between vi...

journal_title：Microbial pathogenesis

authors： Salimzadeh L,Bagheri N,Zamanzad B,Azadegan-Dehkordi F,Rahimian G,Hashemzadeh-Chaleshtori M,Rafieian-Kopaei M,Sanei MH,Shirzad H

更新日期：2015-03-01 00:00:00

abstract：:Thymol and carvacrol from the class of monoterpene phenols are one of the most potent plant essential oil components possessing antimicrobial effects. Known for their wide bioactive spectrum, these positional isomers of isopropyl cresol deplete ergosterol content, compromise membrane permeability, block efflux pumps a...

journal_title：Microbial pathogenesis

authors： Khan A,Ahmad A,Ahmad Khan L,Padoa CJ,van Vuuren S,Manzoor N

更新日期：2015-03-01 00:00:00

abstract：:Salmonella enterica serovar Pullorum (S. Pullorum) is a worldwide poultry pathogen of considerable economic importance, particularly in those countries with a developing poultry industry. A variety of genes that affect S. Pullorum colonization in chickens had been identified. 2',3'-cyclic phosphodiesterase (cpdB) is t...

journal_title：Microbial pathogenesis

authors： Liu H,Chen L,Wang X,Si W,Wang H,Wang C,Liu S,Li G

更新日期：2015-03-01 00:00:00

abstract：:In the present study, transposon mutagenesis was used to further attenuate Brucella abortus RB51 vaccine strain. Two purD and purF mutants were constructed, characterized and evaluated for attenuation via intracellular survival in murine macrophage-like RAW264.7 and HeLa cells, and by clearance in BALB/c mice. The pur...

journal_title：Microbial pathogenesis

authors： Truong QL,Cho Y,Barate AK,Kim S,Watarai M,Hahn TW

更新日期：2015-02-01 00:00:00

abstract：:Uropathogenic Escherichia coli (UPEC) comprise a heterogeneous group of strains. In a previous epidemiological survey performed on 230 UPEC isolates, five virulence profiles were described, each one defined by the presence of some virulence determinants and by the absence of others. Phylogenetic groups and antibiotic ...

journal_title：Microbial pathogenesis

authors： Poey ME,Laviña M

更新日期：2014-12-01 00:00:00

abstract：:This study was aimed at determining virulence-associated genes among Haemophilus parasuis (H. parasuis) strains, and supplying for the Kielstein-Rapp-Gabrielson serotyping scheme. The subtractive fragments, obtained through suppression subtractive hybridization and reverse Southern blot hybridization, were found to en...

journal_title：Microbial pathogenesis

authors： Yu J,Wu J,Zhang Y,Du Y,Peng J,Chen L,Sun W,Cong X,Xu S,Shi J,Li J,Huang B,Zhu X,Wang J

更新日期：2014-12-01 00:00:00

abstract：:Moritella viscosa is the aetiological agent of winter-ulcer disease in farmed salmonids in the North Atlantic. Previously, two major (typical and variant) genetic clades have been demonstrated within this bacterial species, one of which is almost solely related to disease in Atlantic salmon (Salmo salar). In the prese...

journal_title：Microbial pathogenesis

authors： Karlsen C,Ellingsen AB,Wiik-Nielsen C,Winther-Larsen HC,Colquhoun DJ,Sørum H

更新日期：2014-12-01 00:00:00

abstract：:Because of the close genetic relatedness between apes and humans, apes are susceptible to many human infectious agents and can serve as carriers of these pathogens. Consequently, they present a serious health hazard to humans. Moreover, many emerging infectious diseases originate in wildlife and continue to threaten h...

journal_title：Microbial pathogenesis

authors： Keita MB,Hamad I,Bittar F

更新日期：2014-12-01 00:00:00

abstract：:The ica operon and aap gene are important factors for Staphylococcus epidermidis biofilm formation. However, we found 15 out of 101 S. epidermidis strains isolated from patients had both the ica operon and the aap gene in the genome but could not form biofilms (ica(+)aap(+)/BF(-) isolates). Compared with standard stra...

journal_title：Microbial pathogenesis

authors： Wu Y,Liu J,Jiang J,Hu J,Xu T,Wang J,Qu D

更新日期：2014-11-01 00:00:00

abstract：:The bacterial phylum Synergistetes consists of Gram-negative anaerobes. Oral Synergistetes are divided in two main clusters, namely A and B. Increasing evidence demonstrates their involvement in etiology of oral infections, including apical periodontitis. This condition causes bone loss around the apex of the tooth, s...

journal_title：Microbial pathogenesis

authors： Fernandes Cdo C,Rechenberg DK,Zehnder M,Belibasakis GN

更新日期：2014-08-01 00:00:00

abstract：:Infectious urinary stones account for about 10% of all urinary stones. In 50% of cases urolithiasis is a recurrent illness, which can lead to the loss of a kidney if not properly treated. One of the reasons for recurrence of the disease may be the ability of bacteria to invade urothelial cells, persist in the host cel...

journal_title：Microbial pathogenesis

authors： Torzewska A,Budzyńska A,Białczak-Kokot M,Różalski A

更新日期：2014-06-01 00:00:00

abstract：:Toxoplasma species are obligate intracellular protozoan which are responsible for induction of several forms of Toxoplasmosis in humans. The mechanisms responsible for the progression of the prolonged forms of Toxoplasmosis and associated pathologies are yet to be identified. However, previous studies proposed that im...

journal_title：Microbial pathogenesis

authors： Zare-Bidaki M,Hakimi H,Abdollahi SH,Zainodini N,Arababadi MK,Kennedy D

更新日期：2014-04-01 00:00:00

abstract：:Brucellosis, a disease caused by the gram-negative bacterium Brucella spp., is a widespread zoonosis that inflicts important animal and human health problems, especially in developing countries. One of the hallmarks of Brucella infection is its capacity to establish a chronic infection, characteristic that depends on ...

journal_title：Microbial pathogenesis

authors： Spera JM,Comerci DJ,Ugalde JE

更新日期：2014-02-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase (HMGR), an NADPH dependant enzyme catalyzes the synthesis of mevalonic acid from HMG-CoA required for isoprenoid biosynthesis. The HMGR gene from Leishmania donovani was cloned and expressed. Genome analysis of L. donovani revealed that HMGR gene having an open readin...

journal_title：Microbial pathogenesis

authors： Dinesh N,Pallerla DS,Kaur PK,Kishore Babu N,Singh S

更新日期：2014-01-01 00:00:00

abstract：:We analyzed the complete genomic sequences of 17 porcine reproductive and respiratory syndrome virus (PRRSV) isolates from Southern China obtained between 2010 and 2011 and found that four of seven isolates from 2011 were closely related to the JXA1-R strain (vaccine virus of JXA1). This close relationship between fie...

journal_title：Microbial pathogenesis

authors： Zhang M,Xie J,Sun L,Cao Z,Gu H,Deng S,Chen Y,Cao Z,Tang F,Su S,Zhang G

更新日期：2013-12-01 00:00:00

abstract：:Lack of a system for genetic manipulation of Chlamydia trachomatis has been a key challenge to advancing understanding the molecular genetic basis of virulence for this bacterial pathogen. We developed a non-viral, dendrimer-enabled system for transformation of this organism and used it to characterize the effects of ...

journal_title：Microbial pathogenesis

authors： Kannan RM,Gérard HC,Mishra MK,Mao G,Wang S,Hali M,Whittum-Hudson JA,Hudson AP

更新日期：2013-12-01 00:00:00

abstract：:Enteropathogenic Escherichia coli (EPEC) uses a type III secretion system (T3SS) to inject effectors into host cells and alter cellular physiology. The aim of the present study was to identify targets of human secretory immunoglobulin A (sIgA) antibodies from the proteins delivered by EPEC into HEp-2 cells after infec...

journal_title：Microbial pathogenesis

authors： Gavilanes-Parra S,Mendoza-Hernández G,Chávez-Berrocal ME,Girón JA,Orozco-Hoyuela G,Manjarrez-Hernández A

更新日期：2013-11-01 00:00:00

abstract：:CpG DNA is a potent activator of the innate immune system. Here the protective effects of CpG DNA are assessed against the facultative intracellular pathogen Francisella tularensis. Dosing of mice with CpG DNA provided protection against disease caused by F. tularensis subsp. holarctica live vaccine strain (LVS) but d...

journal_title：Microbial pathogenesis

authors： Rees DG,Hartley MG,Green M,Lukaszewski RA,Griffin KF,Atkins HS,Lyons R,Krieg AM,Titball RW

更新日期：2013-10-01 00:00:00

abstract：:Group B Streptococcus (GBS) is an important pathogen and is associated with sepsis and meningitis in neonates and infants. An ex vivo model that facilitates observations of GBS interactions with multiple host cell types over time was used to study its pathogenicity. GBS infections were associated with profound reducti...

journal_title：Microbial pathogenesis

authors： Kling DE,Tsvang I,Murphy MP,Newburg DS

更新日期：2013-08-01 00:00:00

abstract：:Upon oxygen shift-down, Mycobacterium tuberculosis complex bacteria can induce a genetic program characterized by halted duplication, which is called Non-replicating persistence (NRP). During this phase, at least 48 genes, collectively named Dormancy survival regulator (DosR) regulon, are important for the long-term s...

journal_title：Microbial pathogenesis

authors： Jiménez BA,Hinojoza-Loza E,Flores-Valdez MA,Prado-Montes de Oca E,Allen K,Estrada-Chávez C,Herrera-Rodríguez S,Flores-Fernández JM,Martínez-Velázquez M,Hernández-Gutiérrez R,Alvarez AH

更新日期：2013-08-01 00:00:00

abstract：:Initial Enterococcus faecalis-endothelial cell molecular interactions which lead to enterococci associating in the host endothelial tissue, colonizing it and proliferating there can be assessed using in vitro models. Cultured human umbilical vein endothelial cells (HUVEC) have been used to study other Gram-positive ba...

journal_title：Microbial pathogenesis

authors： Millán D,Chiriboga C,Patarroyo MA,Fontanilla MR

更新日期：2013-04-01 00:00:00

abstract：:We report the study of a predicted outer-membrane leptospiral protein encoded by the gene lic11207. This protein is conserved in several pathogenic leptospiral strains but is absent in the saprophyte Leptospira biflexa. This putative outer-membrane protein has a domain of unknown function (DUF) 1565 found in several p...

journal_title：Microbial pathogenesis

authors： Pretre G,Lapponi MJ,Atzingen MV,Schattner M,Nascimento AL,Gómez RM

更新日期：2013-03-01 00:00:00

abstract：:Avian pathogenic Escherichia coli (APEC) causes avian colibacillosis, the most significant infectious bacterial disease of poultry worldwide. LuxS, the product of the luxS gene, mediates the quorum sensing (QS) mechanism. This involves the production of autoinducer-2 (AI-2), which regulates important physiological tra...

journal_title：Microbial pathogenesis

authors： Han X,Bai H,Liu L,Dong H,Liu R,Song J,Ding C,Qi K,Liu H,Yu S

更新日期：2013-02-01 00:00:00

abstract：:Certain strains of Lactobacillus appear to have a reproducible effect on weight as a weight-gain effect in lean humans and animals or a weight-loss effect in overweight/obese humans and animals. These results are completely sufficient to capture the attention of the scientific community to assess the effect on the wei...

journal_title：Microbial pathogenesis

authors： Million M,Raoult D

更新日期：2013-02-01 00:00:00

abstract：:TLR4 is a membrane sensor for lipopolysaccharide (LPS), a major cell wall component of gram-negative bacteria. In this study, we investigated the role of TLR4 on innate immune responses in immune cells against Acinetobacter baumannii. Bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs) were isolated fr...

journal_title：Microbial pathogenesis

authors： Kim CH,Jeong YJ,Lee J,Jeon SJ,Park SR,Kang MJ,Park JH,Park JH

更新日期：2013-01-01 00:00:00

abstract：:Our earlier studies showed that AhyRI- (AI-1) and LuxS-based (AI-2) quorum sensing (QS) systems were positive and negative regulators of virulence, respectively, in a diarrheal isolate SSU of Aeromonas hydrophila. Recently, we demonstrated that deletion of the QseBC two-component signal transduction system (AI-3 QS in...

journal_title：Microbial pathogenesis

authors： Kozlova EV,Khajanchi BK,Popov VL,Wen J,Chopra AK

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Obesity is associated with alteration of the gut microbiota. In order to clarify the effect of Lactobacillus-containing probiotics (LCP) on weight we performed a meta-analysis of clinical studies and experimental models. We intended to assess effects by Lactobacillus species. METHODS:A broad search with no ...

journal_title：Microbial pathogenesis

authors： Million M,Angelakis E,Paul M,Armougom F,Leibovici L,Raoult D

更新日期：2012-08-01 00:00:00

abstract：:Anthrax lethal factor (LF), a Zn(2+)-dependent metalloprotease, is a key virulence component of anthrax toxin. Here, we used proteolytic assay-based screening to identify novel LF inhibitors from a naturally extracted chemical library. The screening identified four compounds that inhibited in vitro proteolytic activit...

journal_title：Microbial pathogenesis

authors： Park HC,Sung SR,Lim SM,Lee JS,Kim SK,Yoon MY

更新日期：2012-08-01 00:00:00

abstract：:The effect of recombinant Brugia malayi pepsin inhibitor (rBm33) on human monocytes/macrophages has been examined using THP-1 cells. THP-1 cells stimulated with rBm33 showed enhanced levels of expression of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and diminished levels of IL-12, iNOS and anti-inflammatory cytok...

journal_title：Microbial pathogenesis

authors： Sreenivas K,Vijayan K,Babu S,Narayanan RB

更新日期：2012-07-01 00:00:00

abstract：:The present study investigated the possible correlation between carriage of the virulence genes esp and fsrb, production of hemolysin and gelatinase and biofilm formation in human vs. animal enterococcal isolates. A collection of 219 enterococcal isolates recovered from clinical and fecal surveillance samples of hospi...

journal_title：Microbial pathogenesis

authors： Tsikrikonis G,Maniatis AN,Labrou M,Ntokou E,Michail G,Daponte A,Stathopoulos C,Tsakris A,Pournaras S

更新日期：2012-06-01 00:00:00

abstract：:NorA, NorB, and NorC are efflux proteins in the Nor family that regulate the secretion of fluoroquinolones, and MgrA/NorR is a transcription factor of the Nor family. Overexpression of Nor family proteins provides fluoroquinolone resistance in Staphylococcus aureus. However, in coagulase-negative staphylococci (CNS), ...

journal_title：Microbial pathogenesis

authors： Juárez-Verdayes MA,Parra-Ortega B,Hernández-Rodríguez C,Betanzos-Cabrera G,Rodríguez-Martínez S,Cancino-Diaz ME,Cancino-Diaz JC

更新日期：2012-06-01 00:00:00

abstract：:Brucellosis is a worldwide zoonotic infectious disease that has significant economic effects on animal production and human health. The host macrophage -Brucella interaction is critical to the establishment of infections. Thus, the kinetic transcriptional profile of gene expression in macrophages infected with the Bru...

journal_title：Microbial pathogenesis

authors： Liu Q,Han W,Sun C,Zhou L,Ma L,Lei L,Yan S,Liu S,Du C,Feng X

更新日期：2012-05-01 00:00:00

abstract：:In this study an attempt to address the effects of immunosuppression on pathogenesis of peste des petits ruminants (PPR) virus infection was undertaken. Cyclophosphamide and dexamethasone were used to immunosuppress the animals. The drug treated animals exhibited severe leukopaenia and lymphopaenia; one of the indicat...

journal_title：Microbial pathogenesis

authors： Jagtap SP,Rajak KK,Garg UK,Sen A,Bhanuprakash V,Sudhakar SB,Balamurugan V,Patel A,Ahuja A,Singh RK,Vanamayya PR

更新日期：2012-04-01 00:00:00

abstract：:Mycobacterium tuberculosis genome encodes several high and low molecular mass penicillin binding proteins. One such low molecular mass protein is DacB2 encoded by open reading frame Rv2911 of M. tuberculosis which is predicted to play a role in peptidoglycan synthesis. In this study we have tried to gain an insight in...

journal_title：Microbial pathogenesis

authors： Bourai N,Jacobs WR Jr,Narayanan S

更新日期：2012-02-01 00:00:00